The MICHELLE Trial

Dr. Paul Dobesh discusses the MICHELLE trial with co-host, Dr. Tracy Macaulay. 0:00-1:00: Introduction 1:01-4:14: MICHELLE trial overview 4:15-11:10: Risk stratification and current recommendations for thromboprophylaxis 11:11-19:43: Thoughts on the MICHELLE trial and application to current practice 19:44-23:00: Future directions 23:01-24:03: Closing References: MICHELLE Ramacciotti E, Barile Agati L, Calderaro D, et al. Rivaroxaban versusContinue reading “The MICHELLE Trial”

The Cardiovascular Benefits of Exercise and Physical Activity

Dr. Mary Blanton Covell discusses the cardiovascular benefits of exercise and physical activity with co-host, Dr. Tracy Macaulay. 0:00-1:07: Introduction 1:08-5:05: Background 5:06-15:45: Patient Education and Cardiopulmonary Rehabilitation Programs  15:46-22:30: What type of exercise is best? 22:31-24:20: Overall Thoughts 24:21-25:05: Closing References: Netherlands Cardiac Rehab Trial: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2768711 Eijsvogels TMH, Maessen MFH, Bakker EA, et al.Continue reading “The Cardiovascular Benefits of Exercise and Physical Activity”

The SSaSS Trial

Dr. Mary Blanton Covell discusses the SSaSS Trial with co-host, Dr. Tracy Macaulay. 0:00-1:24: Introduction 1:25-5:00: SSaSS Trial Overview 5:01-8:50: Thoughts on the SSaSS Trial 8:51-9:55: Application to Clinical Practice 9:56-11:46: Recent FDA Guidance on Industry Sodium Content 11:47-22:15: Other Dietary Recommendations 22:16 – 23:21: Closing References: SSaSS Trial: Neal B, Tian M, Li N, etContinue reading “The SSaSS Trial”

CardioScripts Classic – Hypertension [Part 2]

Part 2 of the CardioScripts Classics episode on hypertension with Drs. Tracy Macaulay and Liz Wang. 0:00-1:07: Introduction 1:08-5:23: SPRINT Trial 5:23-9:14: Elderly patients with hypertension 9:15-17:50: Hypertension management in Black patients 17:51-21:57: Hypertension nuances 21:58-23:30: Closing References: SPRINT Trial: The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N EnglContinue reading “CardioScripts Classic – Hypertension [Part 2]”

CardioScripts Classic – Hypertension [Part 1]

Drs. Tracy Macaulay and Liz Sulaica discuss hypertension. 0:00-0:45: Introduction 0:46-2:14: Intro of Dr. Liz Sulaica 2:15-4:19: SHEP Trial 4:20-6:19: Syst-Eur Trial 6:20-11:17: ALLHAT Trial 11:18-15:59: ACCOMPLISH Trial 16:00-18:53: HCTZ vs. Chlorthalidone 18:54-22:03: JNC 8 22:04-22:35: Closing References: SHEP Trial: SHEP Cooperative Research Group. Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons WithContinue reading “CardioScripts Classic – Hypertension [Part 1]”

The ADAPTABLE Trial

Dr. Matthew Wanat and CardioScripts co-host, Dr. Liz Sulaica, discuss the ADAPTABLE trial.  0:00-0:25: Introduction  0:26-1:32: Introduction of Dr. Matthew Wanat 1:33-6:25: ADAPTABLE Overview  6:26-10:23: Aspirin Dosing and Overall Thoughts  10:24-12:06: Trial Limitations 12:07:-14:15: Literature and Guidelines for Aspirin in Primary Prevention (see additional references below) 14:16-18:11: Pragmatic Study Design 18:12-19:24: Final Thoughts  19:25-19:57: Closing  References:  ADAPTABLE: Jones WS, Mulder H,Continue reading “The ADAPTABLE Trial”

EMPEROR-Reduced: Reign of the SGLT2 Inhibitors

Dr. Ted Berei and CardioScripts co-host, Dr. Tracy Macaulay, discuss the EMPEROR-Reduced trial.  0:00-0:28: Introduction  0:29-1:05: Introduction of Dr. Ted Berei  1:06-3:40: EMPEROR-Reduced Overview  3:41-5:08: Overall Thoughts  5:09 -11:18: Secondary Endpoints  11:19-19:04: Considerations for Initiation of SGLT2 Inhibitors  19:05-21:21: Final Thoughts  21:22-22:02: Closing  References:  McMurray, John JV, et al. “Dapagliflozin in patients with heart failure and reduced ejection fraction.” New England Journal of Medicine 381.21 (2019): 1995-2008. Continue reading “EMPEROR-Reduced: Reign of the SGLT2 Inhibitors”

POPular TAVI Trial [Cohort A]

Dr. John Lindsley and CardioScripts co-host, Dr. Liz Sulaica, discuss cohort A of the POPular TAVI trial. 0:00-0:28: Introduction 0:29-1:04: Introduction of Dr. John Lindsley 1:05-6:12: Cohort A Overview 6:13-10:18: Overall Thoughts 10:19-12:30: Subclinical Valve Thrombosis 12:31-15:05: Management strategies 15:06-15:52: Final Thoughts 15:53-16:31: Closing References: POPular TAVI Trial [Cohort A]: Brouwer J, Nijenhuis VJ, DelewiContinue reading “POPular TAVI Trial [Cohort A]”

The LoDoCo2 Trial

Dr. Toby Trujillo and CardioScripts co-host, Dr. Tracy Macaulay, discuss the LoDoCo2 trial. 0:00-027: Intro 0:28-1:03: Introduction of Dr. Toby Trujillo 1:04-4:10: LoDoCo2 Trial Overview 4:11-8:10: Overall Thoughts 8:11-9:49: Run-in period and tolerability 9:50-10:28: Monitoring and Infection 10:29-14:00: Fun New Game – Guess That Trial!! (hint – CURE and parallels to LoDoCo2) 14:01-14:59: Polypharmacy andContinue reading “The LoDoCo2 Trial”