The Cardiovascular Benefits of Exercise and Physical Activity

Dr. Mary Blanton Covell discusses the cardiovascular benefits of exercise and physical activity with co-host, Dr. Tracy Macaulay. 0:00-1:07: Introduction 1:08-5:05: Background 5:06-15:45: Patient Education and Cardiopulmonary Rehabilitation Programs  15:46-22:30: What type of exercise is best? 22:31-24:20: Overall Thoughts 24:21-25:05: Closing References: Netherlands Cardiac Rehab Trial: Eijsvogels TMH, Maessen MFH, Bakker EA, et al.Continue reading “The Cardiovascular Benefits of Exercise and Physical Activity”

The SSaSS Trial

Dr. Mary Blanton Covell discusses the SSaSS Trial with co-host, Dr. Tracy Macaulay. 0:00-1:24: Introduction 1:25-5:00: SSaSS Trial Overview 5:01-8:50: Thoughts on the SSaSS Trial 8:51-9:55: Application to Clinical Practice 9:56-11:46: Recent FDA Guidance on Industry Sodium Content 11:47-22:15: Other Dietary Recommendations 22:16 – 23:21: Closing References: SSaSS Trial: Neal B, Tian M, Li N, etContinue reading “The SSaSS Trial”

CardioScripts Classic – Hypertension [Part 2]

Part 2 of the CardioScripts Classics episode on hypertension with Drs. Tracy Macaulay and Liz Wang. 0:00-1:07: Introduction 1:08-5:23: SPRINT Trial 5:23-9:14: Elderly patients with hypertension 9:15-17:50: Hypertension management in Black patients 17:51-21:57: Hypertension nuances 21:58-23:30: Closing References: SPRINT Trial: The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N EnglContinue reading “CardioScripts Classic – Hypertension [Part 2]”

CardioScripts Classic – Hypertension [Part 1]

Drs. Tracy Macaulay and Liz Sulaica discuss hypertension. 0:00-0:45: Introduction 0:46-2:14: Intro of Dr. Liz Sulaica 2:15-4:19: SHEP Trial 4:20-6:19: Syst-Eur Trial 6:20-11:17: ALLHAT Trial 11:18-15:59: ACCOMPLISH Trial 16:00-18:53: HCTZ vs. Chlorthalidone 18:54-22:03: JNC 8 22:04-22:35: Closing References: SHEP Trial: SHEP Cooperative Research Group. Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons WithContinue reading “CardioScripts Classic – Hypertension [Part 1]”


Dr. Matthew Wanat and CardioScripts co-host, Dr. Liz Sulaica, discuss the ADAPTABLE trial.  0:00-0:25: Introduction  0:26-1:32: Introduction of Dr. Matthew Wanat 1:33-6:25: ADAPTABLE Overview  6:26-10:23: Aspirin Dosing and Overall Thoughts  10:24-12:06: Trial Limitations 12:07:-14:15: Literature and Guidelines for Aspirin in Primary Prevention (see additional references below) 14:16-18:11: Pragmatic Study Design 18:12-19:24: Final Thoughts  19:25-19:57: Closing  References:  ADAPTABLE: Jones WS, Mulder H,Continue reading “The ADAPTABLE Trial”


Dr. Stephanie Dwyer Kaluzna and CardioScripts co-host, Dr. Tracy Macaulay, discuss the PARADISE-MI trial.  0:00-0:25: Introduction  0:26-1:19: Introduction of Dr. Stephanie Dwyer Kaluzna 1:20-6:14: PARADISE-MI Overview  6:15-7:56: Overall Thoughts  7:57-10:28: Use of ACE-I/ARB in MI 10:30-13:43: Background Therapy Considerations  13:44-18:08: Applicability and Feasibility of Use 18:09-19:24: Final Thoughts  19:25-20:02: Closing  References:  PARADISE-MI Trial: Design and baseline characteristics: Jering KS, Claggett B,Continue reading “The PARADISE-MI Trial”

EMPEROR-Reduced: Reign of the SGLT2 Inhibitors

Dr. Ted Berei and CardioScripts co-host, Dr. Tracy Macaulay, discuss the EMPEROR-Reduced trial.  0:00-0:28: Introduction  0:29-1:05: Introduction of Dr. Ted Berei  1:06-3:40: EMPEROR-Reduced Overview  3:41-5:08: Overall Thoughts  5:09 -11:18: Secondary Endpoints  11:19-19:04: Considerations for Initiation of SGLT2 Inhibitors  19:05-21:21: Final Thoughts  21:22-22:02: Closing  References:  McMurray, John JV, et al. “Dapagliflozin in patients with heart failure and reduced ejection fraction.” New England Journal of Medicine 381.21 (2019): 1995-2008. Continue reading “EMPEROR-Reduced: Reign of the SGLT2 Inhibitors”

POPular TAVI Trial [Cohort A]

Dr. John Lindsley and CardioScripts co-host, Dr. Liz Sulaica, discuss cohort A of the POPular TAVI trial. 0:00-0:28: Introduction 0:29-1:04: Introduction of Dr. John Lindsley 1:05-6:12: Cohort A Overview 6:13-10:18: Overall Thoughts 10:19-12:30: Subclinical Valve Thrombosis 12:31-15:05: Management strategies 15:06-15:52: Final Thoughts 15:53-16:31: Closing References: POPular TAVI Trial [Cohort A]: Brouwer J, Nijenhuis VJ, DelewiContinue reading “POPular TAVI Trial [Cohort A]”

The LoDoCo2 Trial

Dr. Toby Trujillo and CardioScripts co-host, Dr. Tracy Macaulay, discuss the LoDoCo2 trial. 0:00-027: Intro 0:28-1:03: Introduction of Dr. Toby Trujillo 1:04-4:10: LoDoCo2 Trial Overview 4:11-8:10: Overall Thoughts 8:11-9:49: Run-in period and tolerability 9:50-10:28: Monitoring and Infection 10:29-14:00: Fun New Game – Guess That Trial!! (hint – CURE and parallels to LoDoCo2) 14:01-14:59: Polypharmacy andContinue reading “The LoDoCo2 Trial”