Dr. Sara Ward discusses the SECURE trial with co-host, Dr. Tracy Macaulay

0:00-1:08: Introduction

1:09-3:40: SECURE trial overview

3:41-7:55: History of polypill and overall trial considerations

7:56-11:36: Polypill formulation and titration

11:37-14:04: Antiplatelet therapy in SECURE discussion

14:05-18:06: Polypill use in the US

18:07-19:29: Final thoughts

19:30-20:00: Closing


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Macaulay T, Sheridan E, Ward S. Reconsidering the Polypill for management of cardiovascularrisk factors in underserved patietsion. Curr Cardiol Rep 2021; 23:19.

Yusuf S, Joseph P, Dans A, et al. Polypill with or without aspirin in persons withoutcardiovascular disease. N Engl J Med 2021; 384: 216–28.

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Yusuf S, Lonn E, Pais P, et al. Blood-pressure and cholesterol lowering in persons withoutcardiovascular disease. N Engl J Med 2016; 374: 2032–43.

Castellano JM, Sanz G, Peñalvo JL, et al. A polypill strategy to improve adherence: results fromthe FOCUS project. J Am Coll Cardiol 2014;64:2071-82.

Joseph P, Roshandel G, Gao P, et al. Fixed-dose combination therapies with and without aspirin forprimary prevention of cardiovascular disease: an individual participant data meta-analysis.Lancet2021;398:1133-46.

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