The SSaSS Trial

Dr. Mary Blanton Covell discusses the SSaSS Trial with co-host, Dr. Tracy Macaulay.

0:00-1:24: Introduction

1:25-5:00: SSaSS Trial Overview

5:01-8:50: Thoughts on the SSaSS Trial

8:51-9:55: Application to Clinical Practice

9:56-11:46: Recent FDA Guidance on Industry Sodium Content

11:47-22:15: Other Dietary Recommendations

22:16 – 23:21: Closing


SSaSS Trial: Neal B, Tian M, Li N, et al. Rationale, design, and baseline characteristics of the Salt Substitute and Stroke Study (SSaSS)-A large-scale cluster randomized controlled trial. Am Heart J. 2017;188:109-117. doi:10.1016/j.ahj.2017.02.033

Guidance for Industry: Voluntary Sodium Reduction Goals:

Estruch R, Ros E, Salas-Salvadó J, et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018;378(25):e34. doi:10.1056/NEJMoa1800389

Kim H, Caulfield LE, Garcia-Larsen V, Steffen LM, Coresh J, Rebholz CM. Plant-Based Diets Are Associated With a Lower Risk of Incident Cardiovascular Disease, Cardiovascular Disease Mortality, and All-Cause Mortality in a General Population of Middle-Aged Adults. J Am Heart Assoc. 2019;8(16):e012865. doi:10.1161/JAHA.119.012865

Victor RG, Lynch K, Li N, et al. A Choi Y, Larson N, Steffen LM, et al. Plant-Centered Diet and Risk of Incident Cardiovascular Disease During Young to Middle Adulthood. J Am Heart Assoc. 2021;10(16):e020718. doi:10.1161/JAHA.120.020718

Kaiser J, van Daalen KR, Thayyil A, Cocco MTARR, Caputo D, Oliver-Williams C. A Systematic Review of the Association Between Vegan Diets and Risk of Cardiovascular Disease. J Nutr. 2021;151(6):1539-1552. doi:10.1093/jn/nxab037v

Drouin-Chartier JP, Chen S, Li Y, et al. Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis. BMJ. 2020;368:m513. Published 2020 Mar 4. doi:10.1136/bmj.m513

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