Drs. Tracy Macaulay and Liz Sulaica discuss hypertension.
0:00-0:45: Introduction
0:46-2:14: Intro of Dr. Liz Sulaica
2:15-4:19: SHEP Trial
4:20-6:19: Syst-Eur Trial
6:20-11:17: ALLHAT Trial
11:18-15:59: ACCOMPLISH Trial
16:00-18:53: HCTZ vs. Chlorthalidone
18:54-22:03: JNC 8
22:04-22:35: Closing
References:
SHEP Trial: SHEP Cooperative Research Group. Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension. JAMA 1991;265:3255-3264.
Syst-Eur Trial: Staessen JA, Fagard R, Thijs L, et al. Randomised double-blind comparison of placebo and active treatment for older persons with isolated systolic hypertension. Lancet 1997;350:757-64.
ALLHAT Trial: ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. JAMA 2002;288(23):2981-97.
ACCOMPLISH Trial: Jamerson KJ, Weber MA, Bakris GL, et al. Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients. N Engl J Med 2008; 359:2417-28.
Chlorthalidone vs HCTZ: Hripcsak G, Suchard MA, Shea S, et al. Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs. Hydrochlorothiazide to Treat Hypertension. JAMA Int Med 2020;80(4):542-51.
JNC 8: James PA, Oparil S, Carter BL, et al. 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311(5):507-520.
2017 ACC/AHA Hypertension Guideline: Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2018;71(19):e127-e248.
Ripley TL, Brenner M, Finks S, et al. Key articles and guidelines in the management of hypertension. J Pharm Pract 2015;28(2):146-61.
Wright JT, Fine LJ, Lackland DT, et al. Evidence supporting a systolic BP goal of less than 150 mm Hg in patients aged 60 years or older: the minority view. Ann Intern Med 2014;160(7):499-503.
CardioScripts 