Dr. Toby Trujillo and CardioScripts co-host, Dr. Tracy Macaulay, discuss the LoDoCo2 trial.
0:00-027: Intro
0:28-1:03: Introduction of Dr. Toby Trujillo
1:04-4:10: LoDoCo2 Trial Overview
4:11-8:10: Overall Thoughts
8:11-9:49: Run-in period and tolerability
9:50-10:28: Monitoring and Infection
10:29-14:00: Fun New Game – Guess That Trial!! (hint – CURE and parallels to LoDoCo2)
14:01-14:59: Polypharmacy and When Colchicine??
15:00-15:35: Final Thoughts
15:36-16:09: Closing
References:
LoDoCo2 Trial: Nidorf SM, Fiolet ATL, Mosterd A, et al. Colchicine in Patients with Chronic Coronary Disease. N Engl J Med 2020; 383: 1838-47.
COLCOT Trial: Tardif J, Kouz S, Waters DD, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med 2019; 381: 2497-505.
CANTOS Trial: Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med 2017; 377: 1119-31.
CLEAR SYNERGY Trial: NCT03048825. https://clinicaltrials.gov/ct2/show/NCT03048825
CURE Trial: Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345(7): 494-502.
CardioScripts 