Dr. Robert DiDomenico and CardioScripts co-host, Dr. Tracy Macaulay, discuss the RATE AF trial and all things digoxin: its past role, therapeutic levels, and current and future state!
0:28-1:02: Welcome back and Introduction of Dr. DiDomenico
1:03-4:33: Overview of the RATE-AF trial as presented at ESC 2020 and based on published trial rationale.
4:34-6:40: How did RATE AF confirm or add to our understanding of digoxin use in Atrial Fibrillation
6:41-9:36: If we use digoxin, what levels are you targeting and what goals are you setting?
9:37-11:50: Digoxin in HFpEF patients
11:51-16:26: Digoxin and Mortality
16:27-17:28: Final thoughts
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- Kotecha D, Calvert M, Deeks JJ, et al. A review of rate control in atrial fibrillation, and the rationale and protocol for RATE-AF trial. BMJ Open 2017;7:e015099.
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- Vamos M, Erath JW, Benz AP, et al. Meta-analysis of effects of digoxin on survival in patients with atrial fibrillation or heart failure: An update. Am J Cardiolo 2019;123:69-74.
- DiDomenico RJ, Bress AP, NA-Thalang K, et al. Use of a simplified nomogram to individualize digoxin dosing versus standard dosing practice in patients with heart failure. Pharmacotherapy 2014; 34:1121-31.
- Bauman JL, DiDomenico RJ, Viana M, Fitch M. A method of determining the dose of digoxin for heart failure in the modern era. Arch Intern Med. 2006 Dec 11-25;166(22):2539-45.
- Singh S, Moore H, Karasik PE, et al. Digoxin initiation and outcomes in patients with heart failure (HFrEF and HFpEF) and atrial fibrillation. Am J Med 2002:S0002-9343(20)30528-3.