Episode 1: Heart on AFIRE, Strong Desire to Stop Aspirin

In this episode, we interview Dr. Tracy Macaulay about the AFIRE trial and hear her thoughts on the role of aspirin in patients with atrial fibrillation and stable coronary disease. 

Episode:
0:00-1:38: Intro
1:39-2:35: Introduction of Dr. Tracy Macaulay
2:36-5:19: AFIRE Trial Overview
5:20-7:14: Initial Thoughts
7:15-10:07: AFIRE Population and Rivaroxaban Dosing
10:08-11:06: Dropping Aspirin
11:07-12:11: What about other anticoagulants?
12:12-13:38: Final Thoughts
13:39-14:50: Closing/Discussion of Funding

References:

  • AFIRE Trial: Yasuda S, Kaikita K, Akao M, et al. Antithrombotic therapy for atrial fibrillation with stable coronary disease. N Engl J Med 2019;381:1103-1113.
  • OAC-ALONE Trial: Matsumura-Nakano Y, Shizuta S, Komasa A, et al. Open-label randomized trial comparing oral anticoagulation with and without single antiplatelet therapy in patients with atrial fibrillation and stable coronary artery disease beyond 1 year after coronary stent implantation: OAC-ALONE Study. Circulation 2019; 139:604–616. 
  • WARIS-II Trial: Hurlen M, Abdelnoor M, Smith P, et al. Warfarin, Aspirin, or Both after Myocardial Infarction. N Engl J Med 2002;347:969-974.
  • J-ROCKET AF Study: Hori M, Matsumoto M, Tanahashi N, et al. Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation — the J-ROCKET AF Study. Circ J 2012;76:2104-11.
  • Other: Tanigawa T, Kaneko M, Hashizume K, et al. Model-based dose selection for phase III rivaroxaban study in Japanese patients with non-valvular atrial fibrillation. Drug Metab Pharmacokinet 2013;28:59-70.

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