Dr. Ricky Turgeon discusses the TIME Trial with co-host, Dr. Liz Wang.
0:00-1:09: Introduction
1:10-7:16: TIME trial overview
7:17-9:10: When to take blood pressure medications?
9:11-14:37: Previous trials
14:38-19:08: Thoughts on the TIME trial and key takeaways
19:09-19:34: Closing
References:
TIME Trial
Cardiovascular Outcomes in Adults With Hypertension With Evening Versus Morning Dosing of Usual Antihypertensives in the UK (TIME Study): A Prospective, Randomized, Open-Label, Blinded-Endpoint Clinical Trial. Lancet 2022;Oct 11:[Epub ahead of print].
MAPEC
Hermida RC, Ayala DE, Mojón A, Fernández JR. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int. 2010;27(8):1629-1651. doi:10.3109/07420528.2010.510230
Hygia Chronotherapy Trial
Hermida RC, Crespo JJ, Domínguez-Sardiña M, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2020;41(48):4565-4576. doi:10.1093/eurheartj/ehz754
Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension – Con Side of the Argument
Turgeon RD, Althouse AD, Cohen JB, et al. Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension – Con Side of the Argument. Hypertension. 2021;78(3):871-878. doi:10.1161/HYPERTENSIONAHA.121.16501
CardioScripts 